Second malignancies after childhood noncentral nervous system solid cancer: results from 13 cancer registries
Identifieur interne : 006730 ( Main/Exploration ); précédent : 006729; suivant : 006731Second malignancies after childhood noncentral nervous system solid cancer: results from 13 cancer registries
Auteurs : Milena Maule [Italie] ; Ghislaine Scelo [France] ; Guido Pastore [Italie] ; Paul Brennan [France] ; Kari Hemminki [Allemagne, Suède] ; Jorgen H. Olsen [Danemark] ; Elizabeth Tracey [Australie] ; Eero Pukkala [Finlande] ; Elisabete Weiderpass [Norvège, Suède, Finlande] ; David H. Brewster [Royaume-Uni] ; Sharon Tamaro [Canada] ; Kee-Seng Chia [Singapour, France] ; Vera Pompe-Kirn [Slovénie] ; Erich V. Kliewer [Canada] ; Jon M. Tonita [Canada] ; Carmen Martos [Espagne] ; Jon G. Jonasson [Islande] ; Franco Merletti [Italie] ; Paolo Boffetta [France, États-Unis]Source :
- International journal of cancer [ 0020-7136 ] ; 2011.
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- Pascal (Inist)
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English descriptors
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Abstract
Children diagnosed with noncentral nervous system solid cancers (NCNSSC) experience several adverse late effects, including second malignant neoplasm. The aim of our study was to assess the risk of specific second malignancies after a childhood NCNSSC. Diagnosis and follow-up data on 10,988 cases of NCNSSC in children (0-14 years) were obtained from 13 registries. Standardized incidence ratios (SIRs) with 95% confidence intervals (CI) and cumulative incidence of second malignancies were computed. We observed 175 second malignant neoplasms, yielding a SIR of 4.6, 95% CI: 3.9-5.3. When considering second cancers with at least 10 occurrences, highest relative risks were found for second malignant bone tumors (SIR = 26.4, 16.6-40.0), soft tissue sarcomas (SIR = 14.1, 6.7-25.8) and myeloid leukemia (SIR = 12.7, 6.3-22.8). Significant increased risks for all malignancies combined were observed after sympathetic nervous system tumors (SIR = 11.4, 5.2-21.6), retinoblastomas (SIR = 7.3, 5.4-9.8), renal tumors (SIR = 5.7, 3.8-8.0), malignant bone tumors (SIR = 5.6, 3.7-8.2), soft tissue sarcomas (SIR = 4.7, 3.2-6.8), germ-cell, trophoblastic and other gonadal neoplasms (SIR = 2.5, 1.1-4.9), carcinomas and other malignant epithelial neoplasms (SIR = 2.2, 1.4-3.3). The highest risk of a second malignancy of any type occurred 5 to 9 years after NCNSSC (SIR = 9.9, 6.8-13.9). The cumulative incidence of second malignancies 10 years after the first neoplasm was eight times higher among NCNSSC survivors than in the general population, with the absolute difference between observed and expected cumulative incidence still increasing after 50 years of follow-up. Children who survived a NCNSSC experience a large increased risk of developing a new malignancy, even many years after their initial diagnosis.
Affiliations:
- Allemagne, Australie, Canada, Danemark, Espagne, Finlande, France, Islande, Italie, Norvège, Royaume-Uni, Singapour, Slovénie, Suède, États-Unis
- Auvergne-Rhône-Alpes, Bade-Wurtemberg, District de Karlsruhe, Hovedstaden, Manitoba, Piémont, Rhône-Alpes, Svealand, Écosse, Østlandet
- Copenhague, Heidelberg, Lyon, Oslo, Stockholm, Turin, Winnipeg, Édimbourg
- Université du Manitoba
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Kliewer</name><affiliation wicri:level="1"><inist:fA14 i1="14"><s1>British Columbia Cancer Agency, Vancouver</s1><s2>British Columbia</s2><s3>CAN</s3><sZ>11 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>British Columbia</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="18"><s1>Epidemiology and Cancer Registry, CancerCare Manitoba</s1><s2>Winnipeg</s2><s3>CAN</s3><sZ>14 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Winnipeg</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="19"><s1>Community Health Sciences, University of Manitoba</s1><s2>Winnipeg</s2><s3>CAN</s3><sZ>14 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Winnipeg</settlement><region type="state">Manitoba</region></placeName><orgName type="university">Université du Manitoba</orgName></affiliation></author><author><name sortKey="Tonita, Jon M" sort="Tonita, Jon M" uniqKey="Tonita J" first="Jon M." last="Tonita">Jon M. Tonita</name><affiliation wicri:level="1"><inist:fA14 i1="20"><s1>Saskatchewan Cancer Agency, Regina</s1><s2>Saskatchewan</s2><s3>CAN</s3><sZ>15 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Saskatchewan</wicri:noRegion></affiliation></author><author><name sortKey="Martos, Carmen" sort="Martos, Carmen" uniqKey="Martos C" first="Carmen" last="Martos">Carmen Martos</name><affiliation wicri:level="1"><inist:fA14 i1="21"><s1>Cancer Registry of Zaragoza, Health Department of Aragon Government</s1><s2>Zaragoza</s2><s3>ESP</s3><sZ>16 aut.</sZ></inist:fA14><country>Espagne</country><wicri:noRegion>Zaragoza</wicri:noRegion></affiliation></author><author><name sortKey="Jonasson, Jon G" sort="Jonasson, Jon G" uniqKey="Jonasson J" first="Jon G." last="Jonasson">Jon G. Jonasson</name><affiliation wicri:level="1"><inist:fA14 i1="22"><s1>Icelandic Cancer Registry, Icelandic Cancer Society</s1><s2>Reykjavik</s2><s3>ISL</s3><sZ>17 aut.</sZ></inist:fA14><country>Islande</country><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="23"><s1>Faculty of Medicine, University of Iceland</s1><s2>Reykjavik</s2><s3>ISL</s3><sZ>17 aut.</sZ></inist:fA14><country>Islande</country><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Merletti, Franco" sort="Merletti, Franco" uniqKey="Merletti F" first="Franco" last="Merletti">Franco Merletti</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Childhood Cancer Registry of Piedmont, Cancer Epidemiology Unit, CPO Piemonte, CeRMS, University of Turin</s1><s2>Turin</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Turin</settlement><region type="région" nuts="2">Piémont</region></placeName></affiliation></author><author><name sortKey="Boffetta, Paolo" sort="Boffetta, Paolo" uniqKey="Boffetta P" first="Paolo" last="Boffetta">Paolo Boffetta</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>International Agency for Research on Cancer (IARC)</s1><s2>Lyon</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="24"><s1>The Tisch Cancer Institute, Mount Sinai School of Medicine</s1><s2>New York, NY</s2><s3>USA</s3><sZ>19 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>New York, NY</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">11-0420326</idno><date when="2011">2011</date><idno type="stanalyst">PASCAL 11-0420326 INIST</idno><idno type="RBID">Pascal:11-0420326</idno><idno type="wicri:Area/PascalFrancis/Corpus">001944</idno><idno type="wicri:Area/PascalFrancis/Curation">004612</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">001684</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">001684</idno><idno type="wicri:doubleKey">0020-7136:2011:Maule M:second:malignancies:after</idno><idno type="wicri:Area/Main/Merge">006B35</idno><idno type="wicri:Area/Main/Curation">006730</idno><idno type="wicri:Area/Main/Exploration">006730</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Second malignancies after childhood noncentral nervous system solid cancer: results from 13 cancer registries</title><author><name sortKey="Maule, Milena" sort="Maule, Milena" uniqKey="Maule M" first="Milena" last="Maule">Milena Maule</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Childhood Cancer Registry of Piedmont, Cancer Epidemiology Unit, CPO Piemonte, CeRMS, University of Turin</s1><s2>Turin</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Turin</settlement><region type="région" nuts="2">Piémont</region></placeName></affiliation></author><author><name sortKey="Scelo, Ghislaine" sort="Scelo, Ghislaine" uniqKey="Scelo G" first="Ghislaine" last="Scelo">Ghislaine Scelo</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>International Agency for Research on Cancer (IARC)</s1><s2>Lyon</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Pastore, Guido" sort="Pastore, Guido" uniqKey="Pastore G" first="Guido" last="Pastore">Guido Pastore</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Childhood Cancer Registry of Piedmont, Cancer Epidemiology Unit, CPO Piemonte, CeRMS, University of Turin</s1><s2>Turin</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Turin</settlement><region type="région" nuts="2">Piémont</region></placeName></affiliation></author><author><name sortKey="Brennan, Paul" sort="Brennan, Paul" uniqKey="Brennan P" first="Paul" last="Brennan">Paul Brennan</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>International Agency for Research on Cancer (IARC)</s1><s2>Lyon</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Hemminki, Kari" sort="Hemminki, Kari" uniqKey="Hemminki K" first="Kari" last="Hemminki">Kari Hemminki</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ)</s1><s2>Heidelberg</s2><s3>DEU</s3><sZ>5 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Center for Primary Health Care Research, University of Lund</s1><s2>Malmo</s2><s3>SWE</s3><sZ>5 aut.</sZ></inist:fA14><country>Suède</country><wicri:noRegion>Malmo</wicri:noRegion></affiliation></author><author><name sortKey="Olsen, Jorgen H" sort="Olsen, Jorgen H" uniqKey="Olsen J" first="Jorgen H." last="Olsen">Jorgen H. Olsen</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Institute of Cancer Epidemiology, Danish Cancer Society</s1><s2>Copenhagen</s2><s3>DNK</s3><sZ>6 aut.</sZ></inist:fA14><country>Danemark</country><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Tracey, Elizabeth" sort="Tracey, Elizabeth" uniqKey="Tracey E" first="Elizabeth" last="Tracey">Elizabeth Tracey</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>New South Wales Cancer Registry, Eveleigh</s1><s2>New South Wales</s2><s3>AUS</s3><sZ>7 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>New South Wales</wicri:noRegion></affiliation></author><author><name sortKey="Pukkala, Eero" sort="Pukkala, Eero" uniqKey="Pukkala E" first="Eero" last="Pukkala">Eero Pukkala</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Finnish Cancer Registry, Institute for Statistical and Epidemiological Cancer Research</s1><s2>Helinski</s2><s3>FIN</s3><sZ>8 aut.</sZ></inist:fA14><country>Finlande</country><wicri:noRegion>Helinski</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>School of Public Health, University of Tampere</s1><s2>Tampere</s2><s3>FIN</s3><sZ>8 aut.</sZ></inist:fA14><country>Finlande</country><wicri:noRegion>Tampere</wicri:noRegion></affiliation></author><author><name sortKey="Weiderpass, Elisabete" sort="Weiderpass, Elisabete" uniqKey="Weiderpass E" first="Elisabete" last="Weiderpass">Elisabete Weiderpass</name><affiliation wicri:level="3"><inist:fA14 i1="09"><s1>The Cancer Registry of Norway</s1><s2>Oslo</s2><s3>NOR</s3><sZ>9 aut.</sZ></inist:fA14><country>Norvège</country><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Department of Community Medicine</s1><s2>Tromso</s2><s3>NOR</s3><sZ>9 aut.</sZ></inist:fA14><country>Norvège</country><wicri:noRegion>Department of Community Medicine</wicri:noRegion></affiliation><affiliation wicri:level="3"><inist:fA14 i1="11"><s1>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet</s1><s2>Stockholm</s2><s3>SWE</s3><sZ>9 aut.</sZ></inist:fA14><country>Suède</country><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Samfunded Folkhalsan</s1><s2>Helsinki</s2><s3>FIN</s3><sZ>9 aut.</sZ></inist:fA14><country>Finlande</country><wicri:noRegion>Samfunded Folkhalsan</wicri:noRegion></affiliation></author><author><name sortKey="Brewster, David H" sort="Brewster, David H" uniqKey="Brewster D" first="David H." last="Brewster">David H. Brewster</name><affiliation wicri:level="3"><inist:fA14 i1="13"><s1>Scottish Cancer Registry, Information Services Division, NHS National Services Scotland, Edinburgh</s1><s2>Scotland</s2><s3>GBR</s3><sZ>10 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Tamaro, Sharon" sort="Tamaro, Sharon" uniqKey="Tamaro S" first="Sharon" last="Tamaro">Sharon Tamaro</name><affiliation wicri:level="1"><inist:fA14 i1="14"><s1>British Columbia Cancer Agency, Vancouver</s1><s2>British Columbia</s2><s3>CAN</s3><sZ>11 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>British Columbia</wicri:noRegion></affiliation></author><author><name sortKey="Chia, Kee Seng" sort="Chia, Kee Seng" uniqKey="Chia K" first="Kee-Seng" last="Chia">Kee-Seng Chia</name><affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Center for Molecular Epidemiology</s1><s3>SGP</s3><sZ>12 aut.</sZ></inist:fA14><country>Singapour</country><wicri:noRegion>Center for Molecular Epidemiology</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Singapore Cancer Registry</s1><s3>SGP</s3><sZ>12 aut.</sZ></inist:fA14><country>Singapour</country><wicri:noRegion>Singapore Cancer Registry</wicri:noRegion></affiliation><affiliation wicri:level="3"><inist:fA14 i1="25"><s1>International Prevention Research Institute</s1><s2>Lyon</s2><s3>FRA</s3><sZ>12 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Pompe Kirn, Vera" sort="Pompe Kirn, Vera" uniqKey="Pompe Kirn V" first="Vera" last="Pompe-Kirn">Vera Pompe-Kirn</name><affiliation wicri:level="1"><inist:fA14 i1="17"><s1>Cancer Registry of Slovenia, Institute of Oncology</s1><s2>Ljubljana</s2><s3>SVN</s3><sZ>13 aut.</sZ></inist:fA14><country>Slovénie</country><wicri:noRegion>Ljubljana</wicri:noRegion></affiliation></author><author><name sortKey="Kliewer, Erich V" sort="Kliewer, Erich V" uniqKey="Kliewer E" first="Erich V." last="Kliewer">Erich V. Kliewer</name><affiliation wicri:level="1"><inist:fA14 i1="14"><s1>British Columbia Cancer Agency, Vancouver</s1><s2>British Columbia</s2><s3>CAN</s3><sZ>11 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>British Columbia</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="18"><s1>Epidemiology and Cancer Registry, CancerCare Manitoba</s1><s2>Winnipeg</s2><s3>CAN</s3><sZ>14 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Winnipeg</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="19"><s1>Community Health Sciences, University of Manitoba</s1><s2>Winnipeg</s2><s3>CAN</s3><sZ>14 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Winnipeg</settlement><region type="state">Manitoba</region></placeName><orgName type="university">Université du Manitoba</orgName></affiliation></author><author><name sortKey="Tonita, Jon M" sort="Tonita, Jon M" uniqKey="Tonita J" first="Jon M." last="Tonita">Jon M. Tonita</name><affiliation wicri:level="1"><inist:fA14 i1="20"><s1>Saskatchewan Cancer Agency, Regina</s1><s2>Saskatchewan</s2><s3>CAN</s3><sZ>15 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Saskatchewan</wicri:noRegion></affiliation></author><author><name sortKey="Martos, Carmen" sort="Martos, Carmen" uniqKey="Martos C" first="Carmen" last="Martos">Carmen Martos</name><affiliation wicri:level="1"><inist:fA14 i1="21"><s1>Cancer Registry of Zaragoza, Health Department of Aragon Government</s1><s2>Zaragoza</s2><s3>ESP</s3><sZ>16 aut.</sZ></inist:fA14><country>Espagne</country><wicri:noRegion>Zaragoza</wicri:noRegion></affiliation></author><author><name sortKey="Jonasson, Jon G" sort="Jonasson, Jon G" uniqKey="Jonasson J" first="Jon G." last="Jonasson">Jon G. Jonasson</name><affiliation wicri:level="1"><inist:fA14 i1="22"><s1>Icelandic Cancer Registry, Icelandic Cancer Society</s1><s2>Reykjavik</s2><s3>ISL</s3><sZ>17 aut.</sZ></inist:fA14><country>Islande</country><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="23"><s1>Faculty of Medicine, University of Iceland</s1><s2>Reykjavik</s2><s3>ISL</s3><sZ>17 aut.</sZ></inist:fA14><country>Islande</country><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Merletti, Franco" sort="Merletti, Franco" uniqKey="Merletti F" first="Franco" last="Merletti">Franco Merletti</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Childhood Cancer Registry of Piedmont, Cancer Epidemiology Unit, CPO Piemonte, CeRMS, University of Turin</s1><s2>Turin</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Turin</settlement><region type="région" nuts="2">Piémont</region></placeName></affiliation></author><author><name sortKey="Boffetta, Paolo" sort="Boffetta, Paolo" uniqKey="Boffetta P" first="Paolo" last="Boffetta">Paolo Boffetta</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>International Agency for Research on Cancer (IARC)</s1><s2>Lyon</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="24"><s1>The Tisch Cancer Institute, Mount Sinai School of Medicine</s1><s2>New York, NY</s2><s3>USA</s3><sZ>19 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>New York, NY</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">International journal of cancer</title><title level="j" type="abbreviated">Int. j. cancer</title><idno type="ISSN">0020-7136</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">International journal of cancer</title><title level="j" type="abbreviated">Int. j. cancer</title><idno type="ISSN">0020-7136</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acute myelogenous leukemia</term><term>Cancer</term><term>Cancerology</term><term>Child</term><term>Epidemiology</term><term>Malignant tumor</term><term>Nervous system diseases</term><term>Peripheral nerve disease</term><term>Peripheral nervous system</term><term>Register</term><term>Risk factor</term><term>Second cancer</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Second cancer</term><term>Enfant</term><term>Leucémie aiguë myéloblastique</term><term>Cancer</term><term>Registre</term><term>Cancérologie</term><term>Tumeur maligne</term><term>Système nerveux périphérique</term><term>Facteur risque</term><term>Pathologie du système nerveux périphérique</term><term>Epidémiologie</term><term>Pathologie du système nerveux</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Enfant</term><term>Cancer</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Children diagnosed with noncentral nervous system solid cancers (NCNSSC) experience several adverse late effects, including second malignant neoplasm. The aim of our study was to assess the risk of specific second malignancies after a childhood NCNSSC. Diagnosis and follow-up data on 10,988 cases of NCNSSC in children (0-14 years) were obtained from 13 registries. Standardized incidence ratios (SIRs) with 95% confidence intervals (CI) and cumulative incidence of second malignancies were computed. We observed 175 second malignant neoplasms, yielding a SIR of 4.6, 95% CI: 3.9-5.3. When considering second cancers with at least 10 occurrences, highest relative risks were found for second malignant bone tumors (SIR = 26.4, 16.6-40.0), soft tissue sarcomas (SIR = 14.1, 6.7-25.8) and myeloid leukemia (SIR = 12.7, 6.3-22.8). Significant increased risks for all malignancies combined were observed after sympathetic nervous system tumors (SIR = 11.4, 5.2-21.6), retinoblastomas (SIR = 7.3, 5.4-9.8), renal tumors (SIR = 5.7, 3.8-8.0), malignant bone tumors (SIR = 5.6, 3.7-8.2), soft tissue sarcomas (SIR = 4.7, 3.2-6.8), germ-cell, trophoblastic and other gonadal neoplasms (SIR = 2.5, 1.1-4.9), carcinomas and other malignant epithelial neoplasms (SIR = 2.2, 1.4-3.3). The highest risk of a second malignancy of any type occurred 5 to 9 years after NCNSSC (SIR = 9.9, 6.8-13.9). The cumulative incidence of second malignancies 10 years after the first neoplasm was eight times higher among NCNSSC survivors than in the general population, with the absolute difference between observed and expected cumulative incidence still increasing after 50 years of follow-up. Children who survived a NCNSSC experience a large increased risk of developing a new malignancy, even many years after their initial diagnosis.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Canada</li><li>Danemark</li><li>Espagne</li><li>Finlande</li><li>France</li><li>Islande</li><li>Italie</li><li>Norvège</li><li>Royaume-Uni</li><li>Singapour</li><li>Slovénie</li><li>Suède</li><li>États-Unis</li></country><region><li>Auvergne-Rhône-Alpes</li><li>Bade-Wurtemberg</li><li>District de Karlsruhe</li><li>Hovedstaden</li><li>Manitoba</li><li>Piémont</li><li>Rhône-Alpes</li><li>Svealand</li><li>Écosse</li><li>Østlandet</li></region><settlement><li>Copenhague</li><li>Heidelberg</li><li>Lyon</li><li>Oslo</li><li>Stockholm</li><li>Turin</li><li>Winnipeg</li><li>Édimbourg</li></settlement><orgName><li>Université du Manitoba</li></orgName></list><tree><country name="Italie"><region name="Piémont"><name sortKey="Maule, Milena" sort="Maule, Milena" uniqKey="Maule M" first="Milena" last="Maule">Milena Maule</name></region><name sortKey="Merletti, Franco" sort="Merletti, Franco" uniqKey="Merletti F" first="Franco" last="Merletti">Franco Merletti</name><name sortKey="Pastore, Guido" sort="Pastore, Guido" uniqKey="Pastore G" first="Guido" last="Pastore">Guido Pastore</name></country><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Scelo, Ghislaine" sort="Scelo, Ghislaine" uniqKey="Scelo G" first="Ghislaine" last="Scelo">Ghislaine Scelo</name></region><name sortKey="Boffetta, Paolo" sort="Boffetta, Paolo" uniqKey="Boffetta P" first="Paolo" last="Boffetta">Paolo Boffetta</name><name sortKey="Brennan, Paul" sort="Brennan, Paul" uniqKey="Brennan P" first="Paul" last="Brennan">Paul Brennan</name><name sortKey="Chia, Kee Seng" sort="Chia, Kee Seng" uniqKey="Chia K" first="Kee-Seng" last="Chia">Kee-Seng Chia</name></country><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Hemminki, Kari" sort="Hemminki, Kari" uniqKey="Hemminki K" first="Kari" last="Hemminki">Kari Hemminki</name></region></country><country name="Suède"><noRegion><name sortKey="Hemminki, Kari" sort="Hemminki, Kari" uniqKey="Hemminki K" first="Kari" last="Hemminki">Kari Hemminki</name></noRegion><name sortKey="Weiderpass, Elisabete" sort="Weiderpass, Elisabete" uniqKey="Weiderpass E" first="Elisabete" last="Weiderpass">Elisabete Weiderpass</name></country><country name="Danemark"><region name="Hovedstaden"><name sortKey="Olsen, Jorgen H" sort="Olsen, Jorgen H" uniqKey="Olsen J" first="Jorgen H." last="Olsen">Jorgen H. Olsen</name></region></country><country name="Australie"><noRegion><name sortKey="Tracey, Elizabeth" sort="Tracey, Elizabeth" uniqKey="Tracey E" first="Elizabeth" last="Tracey">Elizabeth Tracey</name></noRegion></country><country name="Finlande"><noRegion><name sortKey="Pukkala, Eero" sort="Pukkala, Eero" uniqKey="Pukkala E" first="Eero" last="Pukkala">Eero Pukkala</name></noRegion><name sortKey="Pukkala, Eero" sort="Pukkala, Eero" uniqKey="Pukkala E" first="Eero" last="Pukkala">Eero Pukkala</name><name sortKey="Weiderpass, Elisabete" sort="Weiderpass, Elisabete" uniqKey="Weiderpass E" first="Elisabete" last="Weiderpass">Elisabete Weiderpass</name></country><country name="Norvège"><region name="Østlandet"><name sortKey="Weiderpass, Elisabete" sort="Weiderpass, Elisabete" uniqKey="Weiderpass E" first="Elisabete" last="Weiderpass">Elisabete Weiderpass</name></region><name sortKey="Weiderpass, Elisabete" sort="Weiderpass, Elisabete" uniqKey="Weiderpass E" first="Elisabete" last="Weiderpass">Elisabete Weiderpass</name></country><country name="Royaume-Uni"><region name="Écosse"><name sortKey="Brewster, David H" sort="Brewster, David H" uniqKey="Brewster D" first="David H." last="Brewster">David H. Brewster</name></region></country><country name="Canada"><noRegion><name sortKey="Tamaro, Sharon" sort="Tamaro, Sharon" uniqKey="Tamaro S" first="Sharon" last="Tamaro">Sharon Tamaro</name></noRegion><name sortKey="Kliewer, Erich V" sort="Kliewer, Erich V" uniqKey="Kliewer E" first="Erich V." last="Kliewer">Erich V. Kliewer</name><name sortKey="Kliewer, Erich V" sort="Kliewer, Erich V" uniqKey="Kliewer E" first="Erich V." last="Kliewer">Erich V. Kliewer</name><name sortKey="Kliewer, Erich V" sort="Kliewer, Erich V" uniqKey="Kliewer E" first="Erich V." last="Kliewer">Erich V. Kliewer</name><name sortKey="Tonita, Jon M" sort="Tonita, Jon M" uniqKey="Tonita J" first="Jon M." last="Tonita">Jon M. Tonita</name></country><country name="Singapour"><noRegion><name sortKey="Chia, Kee Seng" sort="Chia, Kee Seng" uniqKey="Chia K" first="Kee-Seng" last="Chia">Kee-Seng Chia</name></noRegion><name sortKey="Chia, Kee Seng" sort="Chia, Kee Seng" uniqKey="Chia K" first="Kee-Seng" last="Chia">Kee-Seng Chia</name></country><country name="Slovénie"><noRegion><name sortKey="Pompe Kirn, Vera" sort="Pompe Kirn, Vera" uniqKey="Pompe Kirn V" first="Vera" last="Pompe-Kirn">Vera Pompe-Kirn</name></noRegion></country><country name="Espagne"><noRegion><name sortKey="Martos, Carmen" sort="Martos, Carmen" uniqKey="Martos C" first="Carmen" last="Martos">Carmen Martos</name></noRegion></country><country name="Islande"><noRegion><name sortKey="Jonasson, Jon G" sort="Jonasson, Jon G" uniqKey="Jonasson J" first="Jon G." last="Jonasson">Jon G. Jonasson</name></noRegion><name sortKey="Jonasson, Jon G" sort="Jonasson, Jon G" uniqKey="Jonasson J" first="Jon G." last="Jonasson">Jon G. Jonasson</name></country><country name="États-Unis"><noRegion><name sortKey="Boffetta, Paolo" sort="Boffetta, Paolo" uniqKey="Boffetta P" first="Paolo" last="Boffetta">Paolo Boffetta</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|texte= Second malignancies after childhood noncentral nervous system solid cancer: results from 13 cancer registries
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